Endocrine Abstracts

Aim: The aim of the study was the evaluation of the relationship between thyroid size and the result of radioactive iodine therapy in patients treated due to Graves’ hyperthyroidism.Material and methods: The study group included 150 subjects (127 M and 23 F), aged from 20 to 78 years (mean 48.33 years) at the moment of 131I therapy.In all patients the thyroid technetium-99m scan and determination of the serum levels...

Introduction: Iodine is critical for thyroid morphology and function. On the one hand, iodine is a factor leading and permitting to origin of disturbances of thyroid follicular cells function, on the other hand, it’s therapeutic agent.Aim: The aim of the study was to evaluate iodine metabolism in different forms of hyperthyroidism and to analyze relationship between metabolism and thyroid size and function.Material and methods...

Introduction: Hyperthyroidism is one of frequently encountered clinical syndromes appearing in about 2% of adult population. The aim of this study was to evaluate the efficacy of radioiodine treatment in relation to the form of hyperthyroidism.Material and methods: The study investigated 300 patients: 150 with Graves’ disease and 150 with a toxic adenoma goiter (109 with a solitary nodule and 41 with a multinodular goiter). In all the cases, the est...

Introduction: Acromegaly with normal IGF-1level is rarely diagnosed and is difficult to recognize. In acromegalic pa-tients with poorly controlled diabetes, malnutrition, hepatic injury, hepatic congestion due to heart fail-ure, inflammatory diseases, renal dysfunction, and malignant neoplasm, IGF-1 synthesis is inhibited and thus in such cases normal IGF-1 levels may be observed. The aim of the study is to present a rare case of a patient with acromegaly and normal IGF-1 leve...

Introduction: Insulinoma is a rare form of a functional neuroendocrine tumor with an estimated incidence at 1–2 new cases per million persons per year. This infrequent endocrinopathy, frequently escaping standard disease course, constitutes a diagnostic challenge for every endocrinologist. Successful surgical resection of the lesion is the only available method that ensures patient’s full recovery.Case study: 53 years old patient with complaint...

Introduction: Calcium ions (Ca2+) play an essential role in process of correct β-cell insulin secretion. Hypocalcemia impairs insulin secretion leading to glucose metabolism disorders and insulin resistance.Case study: 62 -year old female patient with 18 years history of type 2 diabetes, treated with insulin, suspected of hypoparathyroidism, was admitted to the Department and Clinic of Endocrinology, Medical University of Lublin because o...

Introduction: Atypical pituitary adenomas are often characterized by rapid growth and massive invasion of the surrounding structures. Usually, they are associated with poor prognosis and high recurrence rate due to resistance to conventional therapies. When surgery and radiation are ineffective, alternative therapies remain the last line treatment. Lately, a novel chemotherapy with capecitabine and temozolomide was proposed as a highly effective and extending the life of the p...

Introduction: Adrenal medullary hyperplasia (AMH) is a rare syndrome of catecholamine excess. Adrenal overgrowth is usually bilateral. Due to similar clinical signs, laboratory results and radiological adrenal picture, AMH can be misdiagnosed as pheochromocytoma. The only method that allows determining a proper diagnosis of AMH is pathologic examination. It is regarded as a precursor of pheochromocytoma and has been reported as a component of MEN2.Aim: T...

Introduction: Immunoglobulin-G4-related disease (IgG4RD) is a multidisciplinary problem due to plasmatic cells infiltration and areas of fibrosis in the affected tissues. In IgG4RD, elevation of serum IgG4 immunoglobulins is present. Clinically, the disease is mainly manifested as: autoimmune pancreatitis, salivary gland involvement, sclerosing cholangitis, lymphadenopathy, lachrymal gland enlargement, retroperitoneal fibrosis or orbital pseudotumor. The simultaneous involveme...

Introduction: Type 2 amiodarone-induced thyrotoxicosis (AIT2), resulting from the release of thyroid hormones, is a rarer form of side effect of this drug. Treatment of thyrotoxicosis in patients with end stage renal disease (ESRD) is difficult because hemodialysis alters renal clearance of drugs and iodine, may impact the results of assessment and treatment and can increase the medical instability of patients.Aim: The aim was to present the difficulties...